immunobead test

Antibodies are usually thought of as mechanisms to help prevent infection. Antisperm antibodies, can work against the body by interfering with the reproductive process. In women, antibodies inhibit sperm movement as they make their way through the cervical mucous to reach an egg. In men, antibodies that attach to the sperm’s tail may also impede the sperm’s ability to travel through the cervical mucous.

Antibodies develop due to infections, trauma or other factors. To check for antisperm antibodies, healthcare providers might run an immunobead test (IBT).

why it is done

An IBT can detect different kinds of antisperm antibodies in several biological samples, including blood, cervical mucous and sperm. The test can indicate the class and the severity of the antibodies and what part of the sperm is affected. In a blood sample, an IBT test can reveal whether the antibodies originate from contact with blood or around the reproductive organs.

how it is done

To detect antibodies, blood is drawn from the woman, incubated with a sperm sample and examined under a microscope in the laboratory. Sperm from a semen specimen can also be directly tested for antibodies.

If antisperm antibodies are present, they can be treated in several ways. The first is to correct the defect if it is known. Other options include intrauterine inseminations (IUI) with washed sperm and/or in vitro fertilization (IVF).